Pertussis or whooping cough is a vaccine-preventable disease that still remains a serious infection in neonates and young infants. The disease is particularly severe in infants less than three months old, who are often infected by their parents. Congenital nephrotic syndrome is a rare entity presenting within the first three months. It encompasses a heterogeneous group of entities with genetic, infectious and idiopathic etiologies. In this report we describe a newborn infant who presented with congenital nephrotic syndrome secondary to Bordetella pertussis infection.