Maternal smoking during pregnancy is associated with greater rates of premature deliveries, low birth weight, perinatal morbidity and mortality, and impaired intellectual development. It also causes a three-fold greater risk for intracranial hemorrhage in neonates. To our knowledge no neonatal case with intracranial hemorrhage and hematuria related to heavy maternal smoking has been published to date. In this case report we present a neonate with intracranial hemorrhage and hematuria, which were associated with heavy maternal smoking, to emphasize the importance of heavy maternal smoking as a causal factor in neonatal bleeding.