An 18-month-old girl with tetralogy of Fallot (TOF), mental retardation and multiple infarcts on brain computerized tomography (CT) is presented. Her sineangiocardiograms showed a thrombus (moving from the left ventricle to ascending and abdominal aorta), TOF, right arcus aorta with anomalous origin of left subclavian artery from the descending aorta, honeycombed appearance of the apex and half of the posterior wall of left ventricle and the apex of right ventricle. Her echocardiography (ECHO) examinations revealed depressed left ventricular systolic function and thrombus in the left ventricle apex, with noncompaction of the left ventricle apex and the middle portion of posterior wall, and in the right ventricular apex.