Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families

H Erdem; S Pehlivan; H Topaloğlu; I Togan; M Ozgüç

Original Article

Turk J Pediatr 1997; 39(4): 447-452.

Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families

Authors

H Erdem

S Pehlivan

H Topaloğlu

I Togan

M Ozgüç

Affiliations

Turk J Pediatr 1997; 39(4): 447-452.

Published: October 25, 1997

Abstract

Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the most common genetic causes of death in childhood. The gene for SMA has been mapped to chromosome 5q11.2-13.3. Chromosomal distribution of the alleles of D5S125, MAP1B5' and D5S679 polymorphic microsatellite markers in 14 unrelated Turkish SMA families have been determined. It is observed that the A9 allele of D5S679 has a significant (chi 2: 3.41 p: 0.065) non-random association with mutant chromosomes.

Copyright and license

Copyright © 1997 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

Erdem H, Pehlivan S, Topaloğlu H, Togan I, Ozgüç M. Allele distribution of D5S125, MAP1B5’ and D5S679 microsatellite markers in Turkish spinal muscular atrophy families. Turk J Pediatr 1997; 39: 447-452.