Neonatal lupus syndrome (NLS) is characterized by the presence of cutaneous lupus, congenital heart block or both associated with maternal autoantibodies anti-Ro (SS-A) and anti-La (SS-B). NLS is responsible for more than 80 percent of cases with isolated congenital complete heart block. This report describes a neonate with third-degree atrioventricular block who was born to an anti-Ro (SS-A) positive mother. The dermatological and hematological manifestations of NLS were absent. The infant's clinical condition was good during the two months of follow-up with expectant management.