The clinical and immunologic features of six patients with X-linked agammaglobulinemia (XLA) are presented. The most common presenting manifestations were respiratory and gastrointestinal tract infections. On admittance to the hospital, one patient had a history of recurrent meningitis, another had a dermatomyositis-like syndrome, and still another had a history of recurrent arthritis.

Keywords: agammaglobulinemia, Bruton's disease, T lymphocyte sub-populations