Abstract
The effect of D-penicillamine (DPA), a copper chelator, on the cerebellar maturation of the offspring of pregnant rats is evaluated. Pups of the mothers which received DPA in a daily dose of 300-400 mg during their last six days of gestation, showed an appreciable decrease in body and cerebellum weights, and cerebellar degenerative changes on histological examination. A postnatal diet DPA-free given to lactating mothers appeared to have a significant effect in reversing the cerebellar degenerative changes in their offspring.
Copyright and license
Copyright © 1989 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
