Abstract
D-Penicillamine administered orally in daily doses of 300 mg or 400 mg to pregnant rats during the last six days of gestation caused marked growth retardation, a decrease in the lung weight to body weight ratio and histological features characteristic of pulmonary emphysema in the newborn animals studied. It was also demonstrated that a normal diet given to the dams for a period of three weeks after delivery did not restore the lung tissue of the offspring to normal.
How to cite
1.
Yurdakök M, Topaloğlu H, Haziroğlu R. Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema. Turk J Pediatr 1989; 31: 221-225.