Abstract
We studied 2-0 homozygous sickle cell anemia patients from 16 families and 31 heterozygous parents. In vitro hemoglobin synthesis analysis indicated that α-thalassemia was present in 50% of the Hb SS patients and in 41% of the Hb AS parents. The MCV and MCH values were not reduced in all the patients with α-thalassemia. Clinical and hematologic evaluations of the patients indicated that the coexistence of α-thalassemia in SS patients seems to result in an increase in hemoglobin levels without, however, having any beneficial effect on clinical severity.
Keywords: alpha thalassemia, in vitro hemoglobin synthesis, sickle cell anemia
Copyright and license
Copyright © 1987 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
