The case of a four-month-old infant showing generalized cryptococcosis associated with malabsorption syndrome and A avitaminosis without central nervous system involvement is presented. The diagnosis was made at post-mortem examination by demonstration of the typical morphologic characteristic and staining qualities of the fungi in the tissue sections. The clinical picture and additional histopathologic findings were consistent with those of malabsorption syndrome and A avitaminosis. No similar associations were encountered in the cases reported in the literature on cryptococcosis.