Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. Congenital fibrinogen deficiency complicated with a hematological malignancy can be life threatening.

Case. We present a four-year-old girl with congenital fibrinogen deficiency complicated with acute lymphoblastic leukemia.

Conclusion. This case aims to highlight therapeutic approaches for the management of afibrinogenemia patients with acute leukemia.

Keywords: acute lymphoblastic leukemia, child, congenital afibrinogenemia