This paper reports the observations associated with a brief course of administration of naltrexone (NTX) to two autistic children. One male and one female child, aged 5.3 and 4.4, respectively, completed the trial. The children were placed on NTX for two weeks for six administrations. The dose was 0.5 mg/kg. The Behavior Summarized Evaluation and Childhood Autism Scale were completed by the teacher and the social worker for baseline and post-experimentation observations. The patients' parents were asked to fill out the Parental Satisfaction Survey. Although the literature indicates that NTX is effective in some children, our observations confirm that NTX is effective in the two cases with different degrees of severity of disease.